Week 6 of the college football season is finally here.

There’s several key matchups in the Big Ten this week, including a top four matchup in Penn State-Iowa that could have College Football Playoff implications.

Michigan at Nebraska is another interesting matchup. The Wolverines are 5-0, but the Huskers seem to be in position to pull off the upset after playing better football in recent weeks.

Dallas Mavericks owner Mark Cuban is this week’s guest picker. College GameDay is on location at the Texas State Fair for Texas-Oklahoma.

Here’s the picks from the GameDay crew:

Sports Betting in Big Ten Country

There is big news coming to the upcoming 2022-23 Big Ten football season (and NFL season). Ohio online sports betting and Maryland sports betting are on the way.

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Michigan @ Nebraska

Desmond Howard: Michigan

Mark Cuban: Nebraska

Lee Corso: Michigan

Kirk Herbstreit: Michigan

Penn State @ Iowa

Desmond Howard: Penn State

Mark Cuban: Penn State

Lee Corso: Iowa

Kirk Herbstreit: Penn State

Maryland-Ohio State, Michigan State-Rutgers and Wisconsin-Illinois are the other games in the Big Ten this week.