Michigan and Purdue are set to face off for the first time since the 2022 B1G Championship Game in Indianapolis. The Boilermakers look much different now than the team that captured the B1G West a season ago, and Jim Harbaugh’s program will be a massive favorite for Week 10.

Heading into the week, Circa Sports opened the line at -28 in favor of Michigan with a total set at 45.5 for the match. Fans looking to get in on the action can take advantage of the Michigan Online Casinos to get started.

Overall, Michigan has dominated the head-to-head series with a 46-14 edge against Purdue. The Wolverines have won 5 straight since 2010, but just 2 of those meetings came since the start of the 2017 season.

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In last season’s title game, the Wolverines pulled away from Jeff Brohm’s team for a 43-22 win. Brohm has since left to lead Louisville, and Ryan Walters is in his first year as a head coach.

The matchup does not favor Walters’ squad after giving up 30+ points in back-to-back losses to Nebraska and Ohio State. Michigan is also coming off a bye week after a dominant stretch to open the season.