Oregon is No. 1 in the nation for a reason. For a lot of reasons, actually.

The Ducks are really good, they are really explosive and their defense has been able to adapt to most everything in the program’s 1st season in the Big Ten. But on Saturday afternoon, Oregon will make its first trip to The Big House as a Big Ten team, and with everything on the line right now on the first Saturday of November, its defense will have a unique challenge in preparing to face not 1 but 2 quarterbacks in original starter Davis Warren and the ultra-athletic Alex Orji.

With Michigan’s 3rd quarterback, Jack Tuttle, announcing his medical retirement on social media on Monday, the Wolverines still have 2 signal-callers in the mix heading into Week 10. Defensive lineman Derrick Harmon and the rest of the Ducks’ defense will have to be ready for whatever Michigan throws at them.

“We’re watching film on both of those guys, everything they do well, both of them,” Harmon told reporters on Tuesday. “We have to make sure our personnel is on point in that game.”

The Ducks and Wolverines will kick things off at 3:30 p.m. ET on CBS, as Oregon tries to stay perfect and 5-3 Michigan tries to make its season with a very complex quarterback situation.