As far as No. 1 seeds go, the Michigan Wolverines are flying under the radar. The loss of senior leader Isaiah Livers looms large for Michigan as they prepare to face the LSU Tigers in the second round of the NCAA Tournament.

Let’s take a look at this Michigan vs. LSU matchup with a focus on the betting lines. Here’s a deep dive into this game complete with odds, analysis, and a pick.

Michigan vs. LSU Pick

Michigan (21-4) did enough to earn their No. 1 seed by playing a brutal Big Ten schedule this year. Juwan Howard took over the program from John Beilein in 2019 and hasn’t looked back. Meanwhile, LSU (19-9) is looking to pull off this second round upset.

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Even with the crucial injury to Livers, most college basketball fans are going to have Michigan beating LSU in the second round here. However, Sunday’s games showed us that no one is safe from March Madness. No. 1 Baylor was able to survive and advance against Wisconsin, but Illinois wasn’t so lucky. The Fighting Illini fell to in-state rival Loyola Chicago in their second-round matchup.

Will Michigan take care of business on Monday or will LSU shake things up with the upset? Let’s take a look at the odds and a pick on this game.

Michigan vs. LSU Odds

Here are the latest odds on Michigan vs. LSU on DraftKings Sportsbook:

Michigan is -5 on the spread against LSU. The Wolverines are -215 on the moneyline while the Tigers are +170. The total is set to 148 points.

The point spread is set to a reasonable number here just one game after the Wolverines were massive favorites over Texas Southern in the first round. Michigan pushed on -26 in the first round. This is going to be a much tougher matchup for the Wolverines.

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Why Michigan Will Cover

The injury to Livers was front-page news for Michigan coming into the NCAA Tournament. He is one of the Wolverines’ best players and a go-to guy in clutch situations. But even without Livers, Michigan is stacked with talent at nearly every position.

It all starts with the big man, freshman Hunter Dickinson. The 7-foot-1 center averaged 14.2 points and 7.6 rebounds this year and was named to the All-Big Ten first team. He had 16 points and three blocks in the first-round win over Texas Southern.

Franz Wagner was quiet in the Texas Southern victory, but he’s another dangerous player for the Wolverines. Wagner could be a lottery pick in the upcoming draft and a deep run into the NCAA Tournament would help his draft stock immensely.

LSU is just 3-4 against NCAA Tournament teams this year and Michigan might be the toughest team they end up facing all year long.

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Why LSU Will Cover

LSU was a slight favorite over No. 8 St. Bonaventure in the first round of the NCAA Tournament. They obliterated the Bonnies from start to finish. The game looked more like a 1 vs. 16 matchup than an 8 vs. 9.

The Tigers were led by Cameron Thomas, who dropped 27 points in the win. The freshman guard is a dynamic scorer who can take over a game at any point in time. If the Tigers are going to win this game, Thomas will need to have a monster performance.

The LSU Tigers are 8-7 this year when playing away from home. They faced a tough SEC schedule that prepared them for this moment. If Thomas shows up to play and his supporting cast can supplement the scoring behind him, LSU has a great chance to cover this spread.

Michigan vs. LSU ATS Prediction

Michigan isn’t as dominant as they could be without Livers, but they are still deep enough with talent to beat LSU and cover this spread. If Michigan can play its game and feed Dickinson inside, they should be able to overpower LSU inside.

Michigan vs. LSU ATS Pick: Michigan -5

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