One of the best defensive players in college football is doubtful to be on the field on Saturday.

Oregon defensive end Kayvon Thibodeaux is reportedly “very doubtful” for the Week 2 contest against Ohio State. Bruce Feldman of The Athletic reported the news about 90 minutes before the two teams were set to square off.

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Matt Prehm of 247Sports also reported that Thibodeaux was spotted in street clothes on the sidelines while most of the team was on the field participating in warmups.

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Thibodeaux sustained an injury in Oregon’s opener against Fresno State. In that game, he was credited with 2 tackles, a sack and a forced fumble in a 31-24 victory.

His absence is a huge blow to a Ducks defense that is facing an elite offensive line and some of the most talented skill position players in college football.