The three Clemson players that failed an NCAA drug test will not participate in Saturday’s Cotton Bowl game against Notre Dame after the B samples of the tests yielded the same results.

Dexter Lawrence, Zach Giella and Braden Galloway all failed drug tests, head coach Dabo Swinney announced on Christmas Eve. All three tested positive for a “sliver” of ostarine. The NCAA tested the B sample to ensure there was no false positives, but the results from the B sample were the same as the original.

The three Tigers will not participate on Saturday.

Lawrence’s absence is the most significant, as he’s been an anchor on the defensive line for Clemson all season. He recorded 37 tackles with 7.5 tackles for loss on the year.

Giella and Galloway have had more limited roles for the Tigers.