Saquon Barkley has been ruled out for the New York Giants’ Week 3 contest against the San Francisco 49ers.

The former Penn State standout was injured in the Giants’ 31-28 Sunday win over the Arizona Cardinals.

Barkley is dealing with an ankle sprain. A Monday report from ESPN’s Adam Schefter stated that Barkley was expected to miss 3 weeks.

On Tuesday, however, New York head coach Brian Daboll shared a more optimistic outlook. At that time, Daboll left the door open for Thursday’s game, calling Barkley a “quick healer.” After the San Francisco game, the Giants don’t play again until Oct. 2 against the Seattle Seahawks on “Monday Night Football.”

Barkley had just 12 carries for 51 yards in New York’s Week 1 blowout loss to rival Dallas. He had 17 carries for 63 yards and 1 rushing touchdown, along with 6 catches for 29 yards and a receiving score in the Week 2 contest before exiting with the ankle injury.

In his sixth professional season, Barkley is closing in on 1,000 carries and looking to cross the 5,000-yard milestone. He has 983 rushes for 4,363 yards in 62 career regular-season games.

Plenty of fans will be following closely to see if Barkley is able to return in Week 4.